Click on your Flag to Shop in your Country

Shop in your country to save on shipping and import fees. Click your flag above to save.

Pharmanex® M-Smart™

Pharmanex® M-Smart™

$75.00 USD
$75.00 USD $75.00 USD
Shipping calculated at checkout.

Order this product at NuSkin.com

Easily subscribe to all Nu Skin products to save 10% and enjoy automatic delivery every one, two, or three months.

30 Stick Packs—3.35 g (0.12 oz) each

This innovative supplement helps support a healthy blood glucose response to multiple types of carbohydrates after eating* - including both starches and sugars. It also promotes balanced energy levels, which can help reduce food cravings, snacking, and hunger. Make your meals even healthier by adding fiber and supporting digestion with every serving.

Energy spikes and crashes after a meal are often caused by meals rich in carbohydrates (sugars and starches), resulting in a quick energy spike, followed by a rapid crash as the body works to counteract the spike. M-Smart supports your body’s ability to respond to carbohydrates healthily, promoting a balanced, healthy response to what you just ate.

We recommend you take M-Smart once a day, right before any meal.

Leaders Beauty & Wellness is an independent reseller and authorized brand affiliate operated by Tara Langdale (Nu Skin Affiliate ID: USN1728661). Orders may ship directly from Leaders Beauty & Wellness or from Nu Skin.
Nu Skin Collections

Best Sellers

Look your best or feel your best? Why choose? As leaders in connected beauty and wellness, we understand the importance of targeting both external skincare and internal nutrition to truly level up your results. And we continue to prove it, again and again.


Pharmanex Supplements

14 items

ageLoc Beauty Devices

5 items

MYND360 Supplements

3 items
youtube Load video: Nu Skin Prysm iO

Leaders Blog

What Are the Benefits of IgG Supplements?

What Are the Benefits of IgG Supplements?

A Detailed Look at Immunoglobulin G, Gut Immunity, and Whole-Body Support Interest in immune health has grown significantly in recent years, and with it, curiosity about targeted immune nutrients. One category that has gained attention is IgG supplements — particularly those derived from bovine colostrum. But what are the actual benefits of IgG supplements? Are they primarily for immune support, digestive health, or both? And how do they work inside the body? This in-depth guide explains what IgG is, how oral IgG supplements function in the gut, and the evidence-backed benefits associated with consistent use. What Is IgG? Immunoglobulin G (IgG) is the most abundant antibody in human circulation. Antibodies are specialized immune proteins produced by B cells that recognize and bind to foreign substances such as bacteria, viruses, and toxins. IgG plays several key roles in immune defense: Neutralizing pathogens Binding toxins and microbial fragments Supporting immune cell communication Helping regulate immune responses While IgG is naturally produced by the body, IgG supplements — often derived from bovine colostrum — are taken orally to support gut-associated immune health. Order on subscription to save 10% at NuSkin.com Easily subscribe to all Nu Skin products to save 10% and enjoy automatic delivery every one, two, or three months. Subscribe & Save 10% $100/month for 3 months = $50 Gift Card $250/month for 3 months = $150 Gift Card   How Oral IgG Supplements Work Unlike injected immune globulin therapies used in medical settings, oral IgG supplements are designed to function primarily in the gastrointestinal tract. According to information from the Mayo Clinic on bovine immune globulin products, oral immune globulin can bind microbial components in the gut and support intestinal balance. It is not absorbed into the bloodstream in large amounts. Instead, it works locally within the digestive tract. This local action is central to many of the reported benefits of IgG supplementation. Key Benefits of IgG Supplements 1. Supports Gut Barrier Integrity The gut lining acts as a protective barrier, allowing nutrients to pass into the bloodstream while keeping unwanted substances out. When this barrier becomes compromised, digestive symptoms and immune strain may follow. Research has shown that bovine colostrum supplementation may help reduce markers of intestinal permeability. For example, a study published in Nutrients found that oral bovine colostrum decreased intestinal permeability markers in athletes. By supporting the structural integrity of the gut lining, IgG supplementation may contribute to a healthier digestive environment. 2. Binds Microbial Toxins and Antigens One of IgG’s primary biological functions is binding antigens — substances that trigger immune responses. In the gut, IgG can bind to bacterial fragments, endotoxins, and other microbial components. This binding action may help reduce irritation and support a more balanced intestinal environment. By limiting interactions between unwanted microbial byproducts and the intestinal lining, IgG can help promote digestive comfort. 3. Supports Coordinated Immune Response The gut houses a significant portion of the immune system. Immune cells in the intestinal lining include: Natural Killer (NK) cells T lymphocytes B lymphocytes Dendritic cells IgG supports immune recognition and signaling. Some research has demonstrated that certain colostrum-derived compounds and associated postbiotics can help activate plasmacytoid dendritic cells (pDCs), which help coordinate broader immune responses. This coordinated immune activity supports resilience during seasonal challenges and environmental stressors. 4. May Reduce Occasional Digestive Discomfort By supporting gut barrier integrity and modulating immune activity in the digestive tract, IgG supplements may help reduce occasional bloating, abdominal discomfort, and irregular digestion in some individuals. Because the action is local to the gut, improvements are often gradual and related to consistent daily use rather than immediate symptom suppression. 5. Supports Respiratory and Systemic Immune Health Some randomized controlled trials examining bovine colostrum and related immune-support compounds have shown reductions in symptoms associated with common colds and influenza in healthy adults. For example: Jounai et al., PLoS One (2012), demonstrated immune activation pathways involving dendritic cells. Fujii et al., Journal of Functional Foods (2017), evaluated immune parameters and antiviral responses in healthy adults. Cesarone et al., Clinical and Applied Thrombosis/Hemostasis (2007), examined colostrum in comparison to influenza vaccination in specific populations. While IgG supplements are not vaccines and are not intended to prevent disease, these studies suggest potential immune-support benefits. 6. Provides Natural Immune Proteins from Colostrum Colostrum is often described as nature’s first immune nutrition. It contains concentrated immune proteins, including IgG. High-quality colostrum supplements are typically standardized to ensure consistent IgG content. Standardization helps provide predictable dosing and potency. Who Might Benefit from IgG Supplements? IgG supplements may be appropriate for: Adults seeking proactive immune support Individuals experiencing occasional digestive discomfort Those under high stress or seasonal immune strain People interested in gut barrier support They are not intended to diagnose, treat, cure, or prevent disease. Individuals with milk allergies should avoid bovine-derived colostrum products. How Long Do IgG Supplements Take to Work? Because IgG works primarily by supporting the gut environment, results typically depend on consistent daily use. Some individuals may notice digestive improvements within weeks, while broader immune-support benefits may develop over longer periods of regular supplementation. Are IgG Supplements Safe? According to the Mayo Clinic, oral bovine immune globulin products are generally considered safe when used as directed. Most benefits are localized to the gut, and systemic absorption is minimal. As with any supplement, individuals who are pregnant, nursing, taking medications, or managing health conditions should consult a healthcare professional before beginning use. Final Thoughts: The Benefits of IgG Supplements IgG supplements, particularly those derived from bovine colostrum, may offer several potential benefits: Supporting intestinal barrier integrity Binding microbial toxins in the gut Promoting coordinated immune activity Enhancing digestive comfort Supporting respiratory and seasonal immune resilience Because the gut is deeply connected to immune function, supporting gut-associated immune proteins like IgG may have broader effects on overall wellness. For individuals seeking targeted immune and digestive support, IgG supplementation represents a research-backed option grounded in the biology of immune protection. References Mayo Clinic. Immune globulin (bovine), oral route. Hałasa M et al. Oral Supplementation with Bovine Colostrum Decreases Intestinal Permeability. Nutrients. 2017. Jounai K et al. Activation of plasmacytoid dendritic cells. PLoS One. 2012. Fujii T et al. Effects of heat-killed Lactococcus lactis on immune parameters. Journal of Functional Foods. 2017. Cesarone MR et al. Prevention of influenza episodes with colostrum. Clin Appl Thromb Hemost. 2007.

Learn more
Prysm iO and the Future of Measurable Wellness

Prysm iO and the Future of Measurable Wellness

How Antioxidant Scanning, Nutrition, and Lifestyle Work Together to Improve Cellular Health For decades, wellness advice has relied on assumptions: eat more vegetables, take supplements, reduce stress, get better sleep. While these recommendations are well-intentioned, they often leave people wondering whether their efforts are actually improving their health at a cellular level. Prysm iO represents a shift away from guesswork and toward measurable wellness — allowing individuals to see how nutrition, lifestyle, and supplementation influence antioxidant status over time.   What Prysm iO Measures and Why It Matters Prysm iO is a non-invasive bio-scanning device developed by Nu Skin that measures skin carotenoid levels, a scientifically validated biomarker of antioxidant status. Carotenoids are powerful antioxidants found in colorful fruits and vegetables. Unlike short-term blood markers, carotenoids accumulate in the skin over time, offering insight into:   Long-term dietary quality Nutrient absorption Oxidative stress load Overall cellular defense Because oxidative stress plays a role in aging, inflammation, immune function, and chronic disease risk, tracking antioxidant status provides a meaningful window into internal health.   View Product The Science Behind Bio-Scanning Technology Bio-scanning technology existed long before modern fitness wearables. Its original purpose was to assess internal biological markers, not external activity metrics. Prysm iO uses advanced optical sensing and artificial intelligence to analyze how specific wavelengths of light interact with carotenoids in the skin. Thousands of spectral data points are captured during each scan, then interpreted through machine-learning calibration to produce a single, easy-to-understand Prysm Score. This approach builds on more than 20 years of carotenoid and antioxidant research and one of the world’s largest antioxidant scan databases.       SAVE 10% Order your Prysm iO at NuSkin.com Easily subscribe to all Nu Skin Supplement to raise your score and save 10% and enjoy automatic delivery every one, two, or three months. Prysm Approved Supplements Subscribe & Save 10% $100/month for 3 months = $50 Gift Card $250/month for 3 months = $150 Gift Card         What Influences Your Prysm iO Score? Your Prysm iO score is not fixed. It reflects a combination of nutrition, absorption, and lifestyle factors, including: Diet Quality Carotenoid intake from fruits and vegetables such as leafy greens, carrots, tomatoes, berries, and citrus plays a foundational role. Nutrient Absorption Even a healthy diet may not translate to high antioxidant levels if digestion, gut health, or fat intake is insufficient. Carotenoids are fat-soluble and require proper absorption to be utilized. Oxidative Stress Load Chronic stress, poor sleep, smoking, environmental toxins, and inflammation increase oxidative demand, potentially lowering antioxidant reserves. Consistency Over Time Because carotenoids accumulate gradually, sustained habits matter far more than short-term changes. The Role of Gut Health in Antioxidant Status Gut health is often overlooked in antioxidant discussions, yet it plays a critical role in nutrient utilization. A balanced microbiome supports:   Efficient digestion Improved micronutrient absorption Reduced systemic inflammation Targeted probiotic support can help optimize how well antioxidant nutrients are absorbed and used by the body, indirectly supporting improved Prysm iO trends over time. Prysm iO–Approved Nutrition and Supplement Support Prysm iO is designed to complement nutritional strategies that directly support the biomarkers it measures. The following products are commonly used as part of an antioxidant-supportive wellness routine:   LifePak® Nano – Advanced multivitamin nutrition with enhanced carotenoid and micronutrient support to promote cellular health. LifePak® Anti-Aging Formula – Comprehensive antioxidant and nutrient blend designed to help protect against oxidative stress. LifePak® Elements – Foundational micronutrient support to help fill dietary gaps. Optimum Omega® – Essential fatty acids that support nutrient absorption, cellular membrane health, and metabolic balance. Pharmanex® G3 Juice – A superfruit juice blend rich in antioxidant compounds that help support carotenoid intake. Nu Biome® – Precision probiotic support designed to promote gut microbiome balance and nutrient utilization. Pharmanex® Jungamals – Nutritional support formulated for children, providing foundational vitamins and antioxidants during growth years. These products are not designed to replace whole foods or healthy habits, but to support consistency and absorption in a modern lifestyle. World Wide Shipping - Purchase your Prysm iO  Antioxidants, Inflammation, and Longevity Oxidative stress and inflammation are closely linked. When free radical production exceeds antioxidant defenses, cellular damage accumulates more rapidly. Over time, this imbalance is associated with:   Accelerated aging Skin and tissue breakdown Immune dysfunction Metabolic challenges By tracking antioxidant status through Prysm iO, individuals gain insight into how effectively their body is defending against oxidative load — a key factor in long-term health and longevity strategies. Why Prysm iO Goes Beyond Traditional Wellness Tracking Most wearable devices measure external behaviors such as steps, heart rate, or sleep duration. Prysm iO focuses on internal response. This distinction matters. Two people can follow the same diet or supplement routine and experience very different outcomes. Prysm iO helps bridge that gap by showing how the body is responding beneath the surface. Using Prysm iO as a Long-Term Wellness Tool Rather than chasing a single number, Prysm iO is most powerful when used to observe trends over time. Many people scan weekly or bi-weekly to:   Monitor the impact of dietary changes Evaluate supplement effectiveness Understand how stress or sleep affects antioxidant levels Stay motivated through visible progress This data-driven approach supports informed decisions rather than assumptions. Final Thoughts Prysm iO represents a new era of wellness — one where nutrition, lifestyle, and supplementation are guided by measurable insight instead of guesswork. By focusing on antioxidant status, it highlights a foundational aspect of cellular health that influences aging, inflammation, and resilience. Wellness is no longer just about what you do. It is about how your body responds.   View Product

Learn more
How to Get Your Nu Skin Prysm iO Score Up

How to Get Your Nu Skin Prysm iO Score Up

Actionable Tips, Strategies, and Approved Products If you’ve used the Prysm iO scanner to check your antioxidant levels, you may be wondering what to do next. Your Prysm iO score reflects your skin carotenoid levels — a meaningful indicator of your body’s antioxidant status influenced by nutrition, lifestyle, absorption, and consistency. Unlike generic wellness metrics, the Prysm iO score isn’t static. With intentional habits and targeted support, you can raise your score over time. Here’s how. We have made it easy with a collection of Prysm io Certified Supplements Here Understanding What Drives Your Prysm iO Score The Prysm iO score tracks carotenoid antioxidants in your skin — compounds abundant in colorful fruits and vegetables and certain supplements. These are some of the most impactful carotenoids:   Beta-carotene Lutein Zeaxanthin Lycopene Astaxanthin Because these molecules accumulate gradually in tissues, consistent intake — not short bursts — leads to the most reliable score improvements.   View Product Core Strategies to Boost Your Score 1. Prioritize Carotenoid-Rich Nutrition A whole-food diet full of colorful produce lays the foundation for higher antioxidant status. Think leafy greens, bright orange and yellow vegetables, tomatoes, berries, and red/purple fruits. Many of these phytonutrients are what Prysm iO actually measures, so food quality matters as much as quantity. 2. Support Absorption With Healthy Fats Carotenoids are fat-soluble nutrients. Including healthy fats (such as olive oil, avocado, or nuts) with your carotenoid foods improves absorption. 3. Reduce Oxidative Stress From Lifestyle Sleep quality, stress management, smoking avoidance, and moderate exercise all help your antioxidant network stay balanced — which shows up in trend-based Prysm results. 4. Stay Consistent and Track Trends Prysm iO scores become most meaningful when tracked over weeks and months, not one-off scans. Many users find that consistent habits build gradual improvements.       SAVE 10% Order your Prysm iO at NuSkin.com Easily subscribe to all Nu Skin Supplement to raise your score and save 10% and enjoy automatic delivery every one, two, or three months. Prysm Approved Supplements Subscribe & Save 10% $100/month for 3 months = $50 Gift Card $250/month for 3 months = $150 Gift Card       Prysm iO-Approved Products That Can Help On the Leaders Beauty & Wellness Prysm iO Approved Products page, a curated list includes foundational nutrition and supplements that support antioxidant intake and overall wellness. Here are top products you can pair with your Prysm iO tracking to help raise your score over time: Prysm iO-Approved Support Supplements   LifePak® Nano – Advanced multivitamin formula with enhanced carotenoids and micronutrients to support overall health and antioxidant levels. LifePak® Anti-Aging Formula – Comprehensive antioxidant and nutrient support designed to help protect against oxidative stress and support long-term well-being. Lifepak® Elements – Essential multivitamin support to help fill nutritional gaps and maintain balanced nutrient intake. Pharmanex® M-Smart™ – Botanical and nutrient support formulated for balanced energy and antioxidant support. Optimum Omega® – Essential fatty acids that support nutrient absorption and cellular health. Nu Biome® – A precision probiotic supporting gut microbiome balance and improved nutrient utilization. Pharmanex® G3 Juice – Antioxidant-rich superfruit juice formulation designed to boost carotenoid intake and support antioxidant status. KIDS Pharmanex® Jungamals – Targeted nutritional support for children with key vitamins and antioxidants to help support healthy growth and development. We have made it easy with a complete collection of Prysm io Certified Supplements Here These are part of the official Prysm Certified product lineup that support carotenoid levels from within and are designed to complement Prysm iO measurements.  Keep in mind that Prysm iO measures internal antioxidant status, so nutritional and systemic support tends to have a more direct effect on score trends than topical products alone.   See Product   See Product   See Product   See Product Lifestyle Habits That Support Your Score To maximize the benefit of antioxidant intake via diet and supplements, focus on:   Sleep quality — Poor sleep increases oxidative stress. Balanced exercise — Regular activity benefits antioxidant defense — overtraining may temporarily elevate stress markers. Stress management — Chronic stress can deplete antioxidant reserves. Smoking cessation and reduced toxin exposure — Minimizes unnecessary oxidative burden. Small adjustments in these areas often reflect in Prysm iO trend lines over time. How Long Does It Take to See Improvements? Because the Prysm iO score reflects cumulative antioxidant accumulation in the skin, most people observe trends over weeks to months, not overnight. Consistency is key. Many users schedule scans weekly or bi-weekly to monitor the effect of dietary changes, supplementation, and lifestyle shifts. Final Thoughts Raising your Prysm iO score is not about chasing a number — it’s about building healthy habits that genuinely support your antioxidant status in a measurable way. Using Prysm-approved nutrition and supplements, prioritizing carotenoid intake, supporting absorption with healthy fats, and maintaining balanced lifestyle practices work together to elevate your score over time.

Learn more